Psychopharmacology Research Group » Publications » Research Papers


Dalla, C. Integrating sex and gender in mental health research: enhanced funding for better treatments. Nat. Mental Health 1, 383–384 (2023).

Papadea, D., Dalla, C., & Tata, D. A. (2023). Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review. Brain sciences13(3), 461., PMID: 36979271

Dandi, Ε., Spandou, E., Dalla, C., & Tata, D. Α. (2023). Τhe neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable mild stress: A systematic review. The European journal of neuroscience, 10.1111/ejn.16089. Advance online publication., PMID: 37461295


Eck, S. R., Kokras, N., Wicks, B., Baltimas, P., Hall, A., van Bendegem, N., Salvatore, M., Cohen, S. R., Bergmann, J., Ceretti, A., Parikh, V., Dalla, C., & Bangasser, D. A. (2022). Corticotropin releasing factor in the nucleus basalis of Meynert impairs attentional performance and reduces levels of glutamate and taurine in male and female rats. Neuropharmacology221, 109280., PMID: 36216029

Pavlidi, P., Kokras, N., & Dalla, C. (2022). Sex Differences in Depression and Anxiety. Current topics in behavioral neurosciences, 10.1007/7854_2022_375. Advance online publication., PMID: 35915385

Kowalczyk, J., Nakos-Bimpos, M., Polissidis, A., Dalla, C., Kokras, N., Skalicka-Woźniak, K., & Budzyńska, B. (2022). Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences. Molecules (Basel, Switzerland)27(4), 1179., PMID: 35208969

Dalla, C., Pavlidi, P., Sakelliadou, D. G., Grammatikopoulou, T., & Kokras, N. (2022). Sex Differences in Blood-Brain Barrier Transport of Psychotropic Drugs. Frontiers in behavioral neuroscience16, 844916., PMID: 35677576


Sil, A., Bespalov, A., Dalla, C., Ferland-Beckham, C., Herremans, A., Karantzalos, K., Kas, M. J., Kokras, N., Parnham, M. J., Pavlidi, P., Pristouris, K., Steckler, T., Riedel, G., & Emmerich, C. H. (2021). PEERS - An Open Science "Platform for the Exchange of Experimental Research Standards" in Biomedicine. Frontiers in behavioral neuroscience15, 755812. PMID: 34744655

Butlen-Ducuing, F., Balkowiec-Iskra, E., Dalla, C., Slattery, D. A., Ferretti, M. T., Kokras, N., Balabanov, P., De Vries, C., Mellino, S., & Santuccione Chadha, A. (2021). Implications of sex-related differences in central nervous system disorders for drug research and development. Nature reviews. Drug discovery20(12), 881–882. PMID: 34226696

Pavlidi, P., Kokras, N., & Dalla, C. (2021). Antidepressants' effects on testosterone and estrogens: what do we know?. European journal of pharmacology, 173998. Advance online publication. DOI: 10.1016/j.ejphar.2021.173998. PMID: 33676942.

Poulia, N., Delis, F., Brakatselos, C., Polissidis, A., Koutmani, Y., Kokras, N., Dalla, C., Politis, P. K., & Antoniou, K. (2021). Detrimental effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol leads to a specific bio-behavioural profile in adult male rats. British journal of pharmacology. DOi: 10.1111/bph.15394. PMID: 33496341.

Sotiropoulos, M. G., Poulogiannopoulou, E., Delis, F., Dalla, C., Antoniou, K., & Kokras, N. (2021). Innovative screening models for the discovery of new schizophrenia drug therapies: an integrated approach. Expert opinion on drug discovery. DOI: 10.1080/17460441.2021.1877657. PMID: 33467920.

Kafetzopoulos, V., Kokras, N., Sousa, N., Antoniou, K., Sotiropoulos, I., & Dalla, C. (2021). Nucleus Reuniens Lesion and Antidepressant Treatment Prevent Hippocampal Neurostructural Alterations Induced by Chronic Mild Stress in Male Rats. Neuroscience. DOI: 10.1016/j.neuroscience.2020.08.017. PMID: 32828941.

Kowalczyk, J., Nakos-Bimpos, M., Polissidis, A., Dalla, C., Kokras, N., Skalicka-Wozniak, K., & Budzynska, B. (2021). Xanthotoxin affects depression-related behavior and neurotransmitters content in a sex-dependent manner in mice. Behavioural brain research. DOI: 10.1016/j.bbr.2020.112985. PMID: 33144177.

Kokras, N., Krokida, S., Varoudaki, T. Z., & Dalla, C. (2021). Do corticosterone levels predict female depressive-like behavior in rodents?. Journal of neuroscience research. DOI: 10.1002/jnr.24686. PMID: 32640495

Dalla, C. (2021). Voices of women in neuroscience. J Neurosci Res. PMID: 32144817 DOI: 10.1002/jnr.24602


Kokras, N., Poulogiannopoulou, E., Sotiropoulos, M. G., Paravatou, R., Goudani, E., Dimitriadou, M., Papakonstantinou, E., Doxastakis, G., Perrea, D. N., Hloupis, G., Angelis, A., Argyropoulou, A., Tsarbopoulos, A., Skaltsounis, A. L., & Dalla, C. (2020). Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content and Sideritis Extract in Female Mice. Molecules (Basel, Switzerland). PMID: 33144177, DOI: 10.3390/molecules25215000 

Cunha, A. M., Guimarães, M. R., Kokras, N., Sotiropoulos, I., Sousa, N., Almeida, A., Dalla, C., & Leite-Almeida, H. (2020). Mesocorticolimbic monoamines in a rodent model of chronic neuropathic pain. Neuroscience letters. PMID: 32818589, DOI: 10.1016/j.neulet.2020.135309

Pawluski, J. L., Kokras, N., Charlier, T. D., Dalla C. (2020). Sex Matters in Neuroscience and Neuropsychopharmacology. Eur J Neurosci. PMID: 32578303 DOI: 10.1111/ejn.14880

Pawluski, J. L., Paravatou, R., Even, A., Cobraiville, G., Fillet, M., Kokras, N., Dalla C. & Charlier, T. D. (2020). Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. DOI: 10.1016/j.neuropharm.2020.107950 PMID: 31935392

Kokras, N., Dioli, C., Paravatou, R., Sotiropoulos, M.G., Delis, F., Antoniou, K., Calogeropoulou, T., Charalampopoulos, I., Gravanis, A., Dalla, C. (2020). Psychoactive Properties of BNN27, a Novel Neurosteroid Derivate, in Male and Female Rats. Phsychopharmacology. PMID: 32506234 DOI: 10.1007/s00213-020-05545-5

Monteiro-Fernandes, D., Silva, J.M., Soares-Cunha, C., Dalla, C., Kokras, N., Arnaud, F., Billiras, R., Zhuravleva, V., Waites, C., Bretin, S., Sousa, N., Sotiropoulos, I. (2020). Allosteric Modulation of AMPA Receptors Counteracts Tau-related Excitotoxic Synaptic Signaling and Memory Deficits in Stress- And Aβ-evoked Hippocampal Pathology. Mol Psychiatry. PMID: 32467647 DOI: 10.1038/s41380-020-0794-5

Karkoula, E., Dagla, I. V., Baira, E., Kokras, N., Dalla, C., Skaltsounis, A. L., Gikas E., & Tsarbopoulos, A. (2020). A novel UHPLC-HRMS-based metabolomics strategy enables the discovery of potential neuroactive metabolites in mice plasma, following ip administration of the main Crocus sativus L. bioactive component. Journal of Pharmaceutical and Biomedical Analysis. DOI: 10.1016/j.jpba.2019.112878 PMID: 31561062


Kokras, N., Sotiropoulos, I., Besinis, D., Tzouveka, E. L., Almeida, O. F. X., Sousa, N., & Dalla, C. (2019). Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes. European Neuropsychopharmacology29(1), 1-15. PMID: 30497839 DOI: 10.1016/j.euroneuro.2018.11.1107

Kokras, N., Hodes, G. E., Bangasser, D. A., & Dalla, C. (2019). Sex differences in the hypothalamic–pituitary–adrenal axis: An obstacle to antidepressant drug development?. British journal of pharmacology, 176(21), 4090-4106. DOI: 10.1111/bph.14710 PMID: 31093959 

Poulia, N., Delis, F., Brakatselos, C., Lekkas, P., Kokras, N., Dalla, C., & Antoniou, K. (2019). Escalating low‐dose Δ9‐tetrahydrocannabinol exposure during adolescence induces differential behavioral and neurochemical effects in male and female adult rats. European Journal of Neuroscience. DOI: 10.1111/ejn.14598 PMID: 31626712

Kokras, N., Papadopoulou, E., Georgiopoulos, G., Dalla, C., Petropoulos, I., Kontogiannis, C., Laina A., Bampatsias D., Stellos K., Kouzoupis A.V., & Stamatelopoulos, K. (2019). The effect of treatment response on endothelial function and arterial stiffness in depression. A prospective study. Journal of affective disorders, 252, 190-200. DOI: 10.1016/j.jad.2019.04.024 PMID: 30986734

Dioli, C., Patrício, P., Sousa, N., Kokras, N., Dalla, C., Guerreiro, S., Santos-Silva M.A., Rego A.C., Pinto L., Ferreiro E., & Sotiropoulos, I. (2019). Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields. Translational psychiatry, 9(1), 1-13. DOI: 10.1038/s41398-019-0477-7 PMCID: PMC6486609


Karkoula, E., Lemonakis, N., Kokras, N., Dalla, C., Gikas, E., Skaltsounis, A. L., & Tsarbopoulos, A. (2018). Trans-crocin 4 is not hydrolyzed to crocetin following ip administration in mice, while it shows penetration through the blood brain barrier. Fitoterapia, 129, 62-72. DOI: 10.1016/j.fitote.2018.06.012 PMID: 29920295

Kokras, N., Pastromas, N., Papasava, D., de Bournonville, C., Cornil, C. A., & Dalla, C. (2018). Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats. Psychoneuroendocrinology87, 93-107. DOI: 10.1016/j.psyneuen.2017.10.007 PMID: 29054014


Gemmel M, Kokras N, Dalla C, Pawluski JL. Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring. Neuropharmacology. 2017 Oct 9. pii: S0028-3908(17)30476-8. doi: 10.1016/j.neuropharm.2017.10.009. [Epub ahead of print] PubMed PMID: 29024676.

Kafetzopoulos V, Kokras N, Sotiropoulos I, Oliveira JF, Leite-Almeida H, Vasalou A, Sardinha VM, Papadopoulou-Daifoti Z, Almeida OF, Antoniou K, Sousa N,  Dalla C. The nucleus reuniens: a key node in the neurocircuitry of stress and depression. Mol Psychiatry. 2017 Apr 11. doi: 10.1038/mp.2017.55. [Epub ahead of print] PubMed PMID: 28397837.

Kokras N, Dalla C. Preclinical sex differences in depression and antidepressant response: Implications for clinical research. J Neurosci Res. 2017 Jan 2;95(1-2):731-736. doi: 10.1002/jnr.23861. Review. PubMed PMID: 27870451.

Kokras N, Baltas D, Theocharis F, Dalla C. Kinoscope: An Open-Source Computer Program for Behavioral Pharmacologists. Front Behav Neurosci. 2017 May 12;11:88. doi: 10.3389/fnbeh.2017.00088. eCollection 2017. PubMed PMID: 28553211; PubMed Central PMCID: PMC5427106.

Gemmel M, Hazlett M, Bögi E, De Lacalle S, Hill LA, Kokras N, Hammond GL, Dalla C, Charlier TD, Pawluski JL. Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress. Psychoneuroendocrinology. 2017 Oct;84:159-171. doi: 10.1016/j.psyneuen.2017.07.480. Epub 2017 Jul 15. PubMed PMID: 28735226.

Carvalho MM, Campos FL, Marques M, Soares-Cunha C, Kokras N, Dalla C, Leite-Almeida H, Sousa N, Salgado AJ. Effect of Levodopa on Reward and Impulsivity in a Rat Model of Parkinson's Disease. Front Behav Neurosci. 2017 Aug 8;11:145. doi: 10.3389/fnbeh.2017.00145. eCollection 2017. PubMed PMID: 28848409; PubMed Central PMCID: PMC5550717.

Spathis AD, Asvos X, Ziavra D, Karampelas T, Topouzis S, Cournia Z, Qing X, Alexakos P, Smits LM, Dalla C, Rideout HJ, Schwamborn JC, Tamvakopoulos C, Fokas D, Vassilatis DK. Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3999-4004. doi: 10.1073/pnas.1616874114. Epub 2017 Mar 27. PubMed PMID: 28348207; PubMed Central PMCID: PMC5393203.

Kokras N, Polissidis A, Antoniou K, Dalla C. Head shaking in the forced swim test: A robust but unexplored sex difference. Pharmacol Biochem Behav. 2017 Jan;152:90-96.  doi: 10.1016/j.pbb.2016.05.007. PubMed PMID: 27184928.


Lopes S, Vaz-Silva J, Pinto V, Dalla C, Kokras N, Bedenk B, Mack N, Czisch M, Almeida OF, Sousa N, Sotiropoulos I. Tau protein is essential for stress-induced brain pathology. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3755-63. doi: 10.1073/pnas.1600953113. PubMed PMID: 27274066; PubMed Central PMCID: PMC4932951.

Gemmel M, Rayen I, van Donkelaar E, Loftus T, Steinbusch HW, Kokras N, Dalla C, Pawluski JL. Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams. Neuroscience. 2016 Jul 7;327:32-43. doi: 10.1016/j.neuroscience.2016.03.068. PubMed PMID: 27060483.

Gemmel M, Rayen I, Lotus T, van Donkelaar E, Steinbusch HW, De Lacalle S, Kokras N, Dalla C, Pawluski JL. Developmental fluoxetine and prenatal stress effects on serotonin, dopamine, and synaptophysin density in the PFC and hippocampus of offspring at weaning. Dev Psychobiol. 2016 Apr;58(3):315-27. doi: 10.1002/dev.21372. PubMed PMID: 26477449.


Morgado P, Marques F, Ribeiro B, Leite-Almeida H, Pêgo JM, Rodrigues AJ, Dalla C, Kokras N, Sousa N, Cerqueira JJ. Stress induced risk-aversion is reverted by D2/D3 agonist in the rat. Eur Neuropsychopharmacol. 2015 Oct;25(10):1744-52. doi: 10.1016/j.euroneuro.2015.07.003. PubMed PMID: 26233608.

Melo A, Kokras N, Dalla C, Ferreira C, Ventura-Silva AP, Sousa N, Pêgo JM. The positive effect on ketamine as a priming adjuvant in antidepressant treatment. Transl Psychiatry. 2015 May 26;5:e573. doi: 10.1038/tp.2015.66. PubMed PMID: 26080090; PubMed Central PMCID: PMC4471295.

Kokras N, Antoniou K, Mikail HG, Kafetzopoulos V, Papadopoulou-Daifoti Z, Dalla C. Forced swim test: What about females? Neuropharmacology. 2015 Dec;99:408-21. doi: 10.1016/j.neuropharm.2015.03.016. Review. PubMed PMID: 25839894


Kokras N, Dalla C. Sex differences in animal models of psychiatric disorders. Br J Pharmacol. 2014 Oct;171(20):4595-619. doi: 10.1111/bph.12710. Review. PubMed PMID: 24697577; PubMed Central PMCID: PMC4209934.

Batzina A, Dalla C, Tsopelakos A, Papadopoulou-Daifoti Z, Karakatsouli N. Environmental enrichment induces changes in brain monoamine levels in gilthead seabream Sparus aurata. Physiol Behav. 2014 May 10;130:85-90. doi: 10.1016/j.physbeh.2014.03.023. PubMed PMID: 24680728.

Kokras N, Pastromas N, Porto TH, Kafetzopoulos V, Mavridis T, Dalla C. Acute  but not sustained aromatase inhibition displays antidepressant properties. Int J Neuropsychopharmacol. 2014 Aug;17(8):1307-13. doi: 10.1017/S1461145714000212. PubMed PMID: 24674846.

Batzina A, Dalla C, Papadopoulou-Daifoti Z, Karakatsouli N. Effects of environmental enrichment on growth, aggressive behaviour and brain monoamines of gilthead seabream Sparus aurata reared under different social conditions. Comp Biochem Physiol A Mol Integr Physiol. 2014 Mar;169:25-32. doi: 10.1016/j.cbpa.2013.12.001. PubMed PMID: 24326244.

Polissidis A, Chouliara O, Galanopoulos A, Naxakis G, Papahatjis D, Papadopoulou-Daifoti Z, Antoniou K. Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute D-amphetamine. Behav Brain Res. 2014 Aug 15;270:261-9. doi: 10.1016/j.bbr.2014.05.029. PubMed PMID: 24867330.

Sfikakis A, Pitychoutis PM, Tsouma A, Messari I, Papadopoulou-Daifoti Z. Effects of testosterone and estradiol on stress-induced adrenal and hippocampal weight changes in female rats. Hormones (Athens). 2014 Jan-Mar;13(1):119-30. PubMed PMID: 24722133.

Batzina, A., Kalogiannis, D., Dalla, C., Papadopoulou-Daifoti, Z., Chadio, S., & Karakatsouli, N. Blue substrate modifies the time course of stress response in gilthead seabream Sparus aurata. Aquaculture. 2014 420:247-253.


Novais A, Ferreira AC, Marques F, Pêgo JM, Cerqueira JJ, David-Pereira A, Campos FL, Dalla C, Kokras N, Sousa N, Palha JA, Sousa JC. Neudesin is involved in anxiety behavior: structural and neurochemical correlates. Front Behav Neurosci. 2013 Sep 9;7:119. doi: 10.3389/fnbeh.2013.00119. PubMed PMID: 24058337; PubMed Central PMCID: PMC3766795.

Bessinis DP, Dalla C, Kokras N, Pitychoutis PM, Papadopoulou-Daifoti Z. Sex-dependent neurochemical effects of environmental enrichment in the visual system. Neuroscience. 2013 Dec 19;254:130-40. doi: 10.1016/j.neuroscience.2013.09.013. PubMed PMID: 24042032.

Pitychoutis PM, Kokras N, Sanoudou D, Dalla C, Papadopoulou-Daifoti Z. Pharmacogenetic considerations for late life depression therapy. Expert Opin Drug Metab Toxicol. 2013 Aug;9(8):989-99. doi: 10.1517/17425255.2013.794786. Review. PubMed PMID: 23641676.

Kyratsas C, Dalla C, Anderzhanova E, Polissidis A, Kokras N, Konstantinides K, Papadopoulou-Daifoti Z. Experimental evidence for sildenafil's action in the central nervous system: dopamine and serotonin changes in the medial preoptic area and nucleus accumbens during sexual arousal. J Sex Med. 2013 Mar;10(3):719-29. doi: 10.1111/j.1743-6109.2012.03000.x. PubMed PMID: 23157427.

Athanasopoulos C, Pitychoutis PM, Messari I, Lionis C, Papadopoulou-Daifoti Z. Is drug utilization in Greece sex dependent? A population-based study. Basic Clin Pharmacol Toxicol. 2013 Jan;112(1):55-62. doi: 10.1111/j.1742-7843.2012.00920.x. PubMed PMID: 22759339.

Polissidis A, Galanopoulos A, Naxakis G, Papahatjis D, Papadopoulou-Daifoti Z, Antoniou K. The cannabinoid CB1 receptor biphasically modulates motor activity and regulates dopamine and glutamate release region dependently. Int J Neuropsychopharmacol. 2013 Mar;16(2):393-403. doi: 10.1017/S1461145712000156. PubMed PMID: 22391102.

Xilouri M, Brekk OR, Landeck N, Pitychoutis PM, Papasilekas T, Papadopoulou-Daifoti Z, Kirik D, Stefanis L. Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration. Brain. 2013 Jul;136(Pt 7):2130-46. doi: 10.1093/brain/awt131. PubMed PMID: 23757764.


Bessinis DP, Dalla C, Daifoti ZP, Tiligada E. Histamine involvement in visual development and adaptation. Invest Ophthalmol Vis Sci. 2012 Nov 1;53(12):7498-503. doi: 10.1167/iovs.12-10809. PubMed PMID: 23060140.

Mikail HG, Dalla C, Kokras N, Kafetzopoulos V, Papadopoulou-Daifoti Z. Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress. Physiol Behav. 2012 Sep 10;107(2):201-6. doi: 10.1016/j.physbeh.2012.06.016. PubMed PMID: 22771833.

Pitychoutis PM, Dalla C, Sideris AC, Tsonis PA, Papadopoulou-Daifoti Z. 5-HT(1A), 5-HT(2A), and 5-HT(2C) receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed. Neuroscience. 2012 May 17;210:152-67. doi: 10.1016/j.neuroscience.2012.03.003. PubMed PMID: 22441040.

Papadopoulou-Daifoti Z. Medications, science and politics: a difficult compromise. Psychiatriki. 2012 Oct-Dec;23(4):291-4. English, Greek, Modern. PubMed PMID: 23399750

Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Perier C, Vila M, Maniati M, Ulusoy A, Kirik D, Park DS, Wada K, Stefanis L. Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. Hum Mol Genet. 2012 Feb 15;21(4):874-89. doi: 10.1093/hmg/ddr521. PubMed PMID: 22076440 


Kokras N, Dalla C, Sideris AC, Dendi A, Mikail HG, Antoniou K, Papadopoulou-Daifoti Z. Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity. Neuropharmacology. 2012 Jan;62(1):436-45. doi: 10.1016/j.neuropharm.2011.08.025. PubMed PMID: 21884710.

Dalla C, Pitychoutis PM, Kokras N, Papadopoulou-Daifoti Z. Sex differences in response to stress and expression of depressive-like behaviours in the rat. Curr  Top Behav Neurosci. 2011;8:97-118. doi: 10.1007/7854_2010_94. Review. PubMed PMID: 21769725.

Kokras N, Dalla C, Papadopoulou-Daifoti Z. Sex differences in pharmacokinetics of antidepressants. Expert Opin Drug Metab Toxicol. 2011 Feb;7(2):213-26. doi: 10.1517/17425255.2011.544250. Review. PubMed PMID: 21192772.

Kokras N, Sotiropoulos I, Pitychoutis PM, Almeida OF, Papadopoulou-Daifoti Z. Citalopram-mediated anxiolysis and differing neurobiological responses in both sexes of a genetic model of depression. Neuroscience. 2011 Oct 27;194:62-71. doi: 10.1016/j.neuroscience.2011.07.077. PubMed PMID: 21839808

Galanopoulos A, Polissidis A, Papadopoulou-Daifoti Z, Nomikos GG, Antoniou K. Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner. Behav Brain Res. 2011 Oct 10;224(1):65-72. doi: 10.1016/j.bbr.2011.05.018. PubMed PMID: 21645556.

Pitychoutis PM, Pallis EG, Mikail HG, Papadopoulou-Daifoti Z. Individual differences in novelty-seeking predict differential responses to chronic antidepressant treatment through sex- and phenotype-dependent neurochemical signatures. Behav Brain Res. 2011 Sep 30;223(1):154-68. doi: 10.1016/j.bbr.2011.04.036. PubMed PMID: 21549763


Pitychoutis PM, Zisaki A, Dalla C, Papadopoulou-Daifoti Z. Pharmacogenetic insights into depression and antidepressant response: does sex matter? Curr Pharm Des. 2010;16(20):2214-23. Review. PubMed PMID: 20459391.

Dalla C, Pitychoutis PM, Kokras N, Papadopoulou-Daifoti Z. Sex differences in animal models of depression and antidepressant response. Basic Clin Pharmacol Toxicol. 2010 Mar;106(3):226-33. doi: 10.1111/j.1742-7843.2009.00516.x. Review. PubMed PMID: 20050844.

Pitychoutis PM, Papadopoulou-Daifoti Z. Of depression and immunity: does sex matter? Int J Neuropsychopharmacol. 2010 Jun;13(5):675-89. doi: 10.1017/S1461145710000465. Review. PubMed PMID: 20478108.

Pitychoutis, P. M., Tsitsilonis, O. E., & Papadopoulou-Daifoti, Z. (2010). Antidepressant pharmacotherapy: focus on sex differences in neuroimmunopharmacological crossroads. Future Neurology, 5(4), 581-596.

Polissidis A, Chouliara O, Galanopoulos A, Rentesi G, Dosi M, Hyphantis T, Marselos M, Papadopoulou-Daifoti Z, Nomikos GG, Spyraki C, Tzavara ET, Antoniou K. Individual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brain. Int J Neuropsychopharmacol. 2010 Oct;13(9):1175-91. doi: 10.1017/S1461145709991003. PubMed PMID: 19941698


Kamper EF, Chatzigeorgiou A, Tsimpoukidi O, Kamper M, Dalla C, Pitychoutis PM, Papadopoulou-Daifoti Z. Sex differences in oxidant/antioxidant balance under  a chronic mild stress regime. Physiol Behav. 2009 Aug 4;98(1-2):215-22. doi: 10.1016/j.physbeh.2009.05.011. PubMed PMID: 19477190.

Dalla C, Shors TJ. Sex differences in learning processes of classical and operant conditioning. Physiol Behav. 2009 May 25;97(2):229-38. doi: 10.1016/j.physbeh.2009.02.035. Review. PubMed PMID: 19272397; PubMed Central PMCID: PMC2699937.

Kokras N, Antoniou K, Polissidis A, Papadopoulou-Daifoti Z. Antidepressants induce regionally discrete, sex-dependent changes in brain's glutamate content. Neurosci Lett. 2009 Oct 23;464(2):98-102. doi: 10.1016/j.neulet.2009.08.011. PubMed PMID: 19666087.

Dalla C, Papachristos EB, Whetstone AS, Shors TJ. Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2927-32. doi: 10.1073/pnas.0809650106. PubMed PMID: 19188598; PubMed Central PMCID: PMC2650367.

Dalla C, Whetstone AS, Hodes GE, Shors TJ. Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females. Neurosci Lett. 2009 Jan 2;449(1):52-6. doi: 10.1016/j.neulet.2008.10.051. PubMed PMID: 18952150; PubMed Central PMCID: PMC3289544.

Kokras N, Antoniou K, Dalla C, Bekris S, Xagoraris M, Ovestreet DH, Papadopoulou-Daifoti Z. Sex-related differential response to clomipramine treatment in a rat model of depression. J Psychopharmacol. 2009 Nov;23(8):945-56. doi: 10.1177/0269881108095914. PubMed PMID: 18755816.

Pitychoutis PM, Griva E, Ioannou K, Tsitsilonis OE, Papadopoulou-Daifoti Z. Chronic antidepressant treatment exerts sexually dimorphic immunomodulatory effects in an experimental model of major depression: do females lack an advantage? Int J Neuropsychopharmacol. 2009 Oct;12(9):1157-63. doi: 10.1017/S1461145709990502. PubMed PMID: 19698192.

Polissidis A, Chouliara O, Galanopoulos A, Marselos M, Papadopoulou-Daifoti Z, Antoniou K. Behavioural and dopaminergic alterations induced by a low dose of  WIN 55,212-2 in a conditioned place preference procedure. Life Sci. 2009 Jul 31;85(5-6):248-54. doi: 10.1016/j.lfs.2009.05.015. PubMed PMID: 19508876.

Pitychoutis PM, Nakamura K, Tsonis PA, Papadopoulou-Daifoti Z. Neurochemical  and behavioral alterations in an inflammatory model of depression: sex differences exposed. Neuroscience. 2009 Apr 10;159(4):1216-32. doi: 10.1016/j.neuroscience.2009.01.072. PubMed PMID: 19409213


Dalla C, Antoniou K, Kokras N, Drossopoulou G, Papathanasiou G, Bekris S, Daskas S, Papadopoulou-Daifoti Z. Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission. Physiol Behav. 2008 Feb 27;93(3):595-605. PubMed PMID: 18031771.

Dalla C, Edgecomb C, Whetstone AS, Shors TJ. Females do not express learned helplessness like males do. Neuropsychopharmacology. 2008 Jun;33(7):1559-69. PubMed PMID: 17712351.

Dalla C, Bangasser DA, Edgecomb C, Shors TJ. Neurogenesis and learning: acquisition and asymptotic performance predict how many new cells survive in the hippocampus. Neurobiol Learn Mem. 2007 Jul;88(1):143-8. PubMed PMID: 17412617; PubMed Central PMCID: PMC2692741.

Sfikakis A, Pitychoutis PM, Antoniou K, Bikas N, Papadopoulou-Daifoti Z. The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats. Hormones (Athens). 2008 Oct-Dec;7(4):303-12. PubMed PMID: 19121991.

Poulopoulou C, Papadopoulou-Daifoti Z, Hatzimanolis A, Fragiadaki K, Polissidis A, Anderzanova E, Davaki P, Katsiari CG, Sfikakis PP. Glutamate levels and activity of the T cell voltage-gated potassium Kv1.3 channel in patients with systemic lupus erythematosus. Arthritis Rheum. 2008 May;58(5):1445-50. doi: 10.1002/art.23446. PubMed PMID: 18438846.

Marazioti, A., Pitychoutis, P. M., Papadopoulou-Daifoti, Z., Spyraki, C., & Thermos, K. (2008). Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum. Psychopharmacology201(3), 413-422.

Antoniou K, Papathanasiou G, Papalexi E, Hyphantis T, Nomikos GG, Spyraki C, Papadopoulou-Daifoti Z. Individual responses to novelty are associated with differences in behavioral and neurochemical profiles. Behav Brain Res. 2008 Mar 5;187(2):462-72. PubMed PMID: 18036673.


Shors TJ, Mathew J, Sisti HM, Edgecomb C, Beckoff S, Dalla C. Neurogenesis and helplessness are mediated by controllability in males but not in females. Biol Psychiatry. 2007 Sep 1;62(5):487-95. PubMed PMID: 17306770; PubMed Central PMCID: PMC2692748.

Karakatsouli, N., Papoutsoglou, S. E., Pizzonia, G., Tsatsos, G., Tsopelakos, A., Chadio, S., Kalogiannis D., Dalla C., Polissidis A., Papadopoulou-Daifoti Z. Effects of light spectrum on growth and physiological status of gilthead seabream Sparus aurata and rainbow trout Oncorhynchus mykiss reared under recirculating system conditions. Aquacultural Engineering. 2007 36(3), 302-309.

Papoutsoglou, S. E., Karakatsouli, N., Louizos, E., Chadio, S., Kalogiannis, D., Dalla, C., Polissidis A., Papadopoulou-Daifoti, Z. Effect of Mozart's music (Romanze-Andante of “Eine Kleine Nacht Musik”, sol major, K525) stimulus on common carp (Cyprinus carpio L.) physiology under different light conditions. Aquacultural engineering, 2007 36(1), 61-72.


Cornil CA, Dalla C, Papadopoulou-Daifoti Z, Baillien M, Balthazart J. Estradiol rapidly activates male sexual behavior and affects brain monoamine levels in the quail brain. Behav Brain Res. 2006 Jan 6;166(1):110-23. PubMed PMID: 16159671

Emmanouil, D. E., Papadopoulou-Daifoti, Z., Hagihara, P. T., Quock, D. G., & Quock, R. M. (2006). A study of the role of serotonin in the anxiolytic effect of nitrous oxide in rodents. Pharmacology Biochemistry and Behavior84(2), 313-320.

Papanikolaou K, Richardson C, Pehlivanidis A, Papadopoulou-Daifoti Z. Efficacy of antidepressants in child and adolescent depression: a meta-analytic study. J Neural Transm (Vienna). 2006 Mar;113(3):399-415. PubMed PMID: 16075184.


Dalla C, Antoniou K, Drossopoulou G, Xagoraris M, Kokras N, Sfikakis A, Papadopoulou-Daifoti Z. Chronic mild stress impact: are females more vulnerable?  Neuroscience. 2005;135(3):703-14. PubMed PMID: 16125862.

Dalla C, Antoniou K, Papadopoulou-Daifoti Z, Balthazart J, Bakker J. Male aromatase-knockout mice exhibit normal levels of activity, anxiety and "depressive-like" symptomatology. Behav Brain Res. 2005 Sep 8;163(2):186-93. PubMed PMID: 16029903.

Cornil CA, Dalla C, Papadopoulou-Daifoti Z, Baillien M, Dejace C, Ball GF, Balthazart J. Rapid decreases in preoptic aromatase activity and brain monoamine concentrations after engaging in male sexual behavior. Endocrinology. 2005 Sep;146(9):3809-20. PubMed PMID: 15932925; PubMed Central PMCID: PMC3909742.

Antoniou K, Papadopoulou-Daifoti Z, Hyphantis T, Papathanasiou G, Bekris E, Marselos M, Panlilio L, Müller CE, Goldberg SR, Ferré S. A detailed behavioural analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors. Psychopharmacology (Berl). 2005 Dec;183(2):154-62. PubMed PMID: 16205915.

Bekris S, Antoniou K, Daskas S, Papadopoulou-Daifoti Z. Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behav Brain Res. 2005 Jun 3;161(1):45-59. PubMed PMID: 15904709.

Antoniou, K., Galanopoulos, A., Vlachou, S., Kourouli, T., Nahmias, V., Thermos, K., Panagis, G., Papadopoulou-Daifoti, Z., Marselos, M., Papahatjis, D., Spyraki, C. Behavioral pharmacological properties of a novel cannabinoid 1′, 1′-dithiolane Δ8-THC analog, AMG-3. Behavioural pharmacology, 2005 16(5-6), 499-510.

Zoidis G, Papanastasiou I, Dotsikas I, Sandoval A, Dos Santos RG, Papadopoulou-Daifoti Z, Vamvakides A, Kolocouris N, Felix R. The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin. Bioorg Med Chem. 2005 Apr 15;13(8):2791-8. PubMed PMID: 15781390.


Dalla C, Antoniou K, Papadopoulou-Daifoti Z, Balthazart J, Bakker J. Oestrogen-deficient female aromatase knockout (ArKO) mice exhibit depressive-like symptomatology. Eur J Neurosci. 2004 Jul;20(1):217-28. PubMed PMID: 15245494.

Drossopoulou G, Antoniou K, Kitraki E, Papathanasiou G, Papalexi E, Dalla C, Papadopoulou-Daifoti Z. Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats. Neuroscience. 2004;126(4):849-57. PubMed PMID: 15207320.

Antoniou K, Papathanasiou G, Panagis G, Nomikos GG, Hyphantis T, Papadopoulou-Daifoti Z. Individual responses to novelty predict qualitative differences in d-amphetamine-induced open field but not reward-related behaviors  in rats. Neuroscience. 2004;123(3):613-23. PubMed PMID: 14706774.


Papagiannopoulou D, Pirmettis I, Tsoukalas Ch, Nikoladou L, Drossopoulou G, Dalla C, Pelecanou M, Papadopoulou-Daifotis Z, Papadopoulos M, Chiotellis E. Oxotechnetium 99mTcO[SN(R)S][S] complexes as potential 5-HT1A receptor imaging agents. Nucl Med Biol. 2002 Nov;29(8):825-32. PubMed PMID: 12453592.

Kioukia-Fougia N, Antoniou K, Bekris S, Liapi C, Christofidis I, Papadopoulou-Daifoti Z. The effects of stress exposure on the hypothalamic-pituitary-adrenal axis, thymus, thyroid hormones and glucose levels. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):823-30. PubMed PMID: 12369253.


Antoniou K, Bekris S, Saranti M, Stathis P, Rimikis M, Papadopoulou-Daifoti Z. The effects of antipsychotic drugs on serotonergic activity in the rat hippocampus. Eur Neuropsychopharmacol. 2000 Sep;10(5):315-24. PubMed PMID: 10974601.

Kioukia N, Bekris S, Antoniou K, Papadopoulou-Daifoti Z, Christofidis I. Effects of chronic mild stress (CMS) on thyroid hormone function in two rat strains. Psychoneuroendocrinology. 2000 Apr;25(3):247-57. PubMed PMID: 10737696.

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